Tip: Testosterone drugs are illegal drugs and have strong side effects. The articles provided by MuscleNet are only for everyone to gain knowledge. We are clearly opposed to using drugs to control hormones to increase muscle!
1. Basic knowledge
Testosterone - the most basic androgenic hormone in the male body is the oldest anabolic steroid but is still an integral part of almost all hard drug cycles. The "BS" - the base steroid and is used in large amounts - no less than the workhorse steroid The dosage shows that testosterone is called "the foundation of all medicines", which is very appropriate.
It is a male hormone that can be secreted by the human body itself. Normal men can produce about 2.5-11mg of testosterone every day. This small amount is enough to promote a pure natural bodybuilder to achieve good results. Because testosterone has very significant muscle-building and strength-building effects. , brush grease. . . Wait, wait, etc., for this reason, the Nazis put a lot of effort into researching how to synthesize it during World War II. Finally, around 1930, the Nazis successfully produced testosterone and attempted to use it to create "super soldiers." This was the first artificial synthesis in the world. Steroids were created by evil forces for evil purposes in the context of World War II. Today, testosterone is active in the dark side of evil bodybuilding as an "evil drug."
Testosterone is an anabolic hormone that can promote muscle anabolism. It binds to the androgen receptor in the muscle and then sends a signal to the muscle to retain protein (increase the protein anabolism rate), thereby increasing the level of positive nitrogen balance and increasing muscle volume. At the same time, testosterone will also weaken the effectiveness of "glucocorticoids" (which send signals to muscles to break down proteins, prompting muscles to break down for energy, thereby causing catabolism), thus protecting the "sweat meat" you have earned through hard exercise from being inexplicably broken down. There is also good news that if testosterone binds to the androgen receptors in fat, it will send signals to the fat——————Decompose signals! Therefore, whether it is for people who want to gain muscle or those who want to lose weight, testosterone has a strong temptation.
On the other hand, testosterone can not only build muscle but also increase strength. Testosterone accelerates the body's production of red blood cells. An increase in red blood cells means that the blood's ability to supply oxygen to the muscles increases, thereby improving muscle strength. This improvement in oxygen supply capacity and muscle strength can be achieved with foreign aid. Particularly significant in the case of testosterone
2. Positive effect
Although testosterone is the earliest and most basic anabolic steroid, its muscle-building performance is still among the best among the current N-class anabolic steroids. So what is the muscle-building effect of testosterone? Let's take a look at the clinical research from "Am J Physiol" Report:
Subjects (trained athletes) were divided into weekly groups - A "25mg group", B "50mg group", C "125mg group", D "300mg group" and E "600mg group" All groups were consecutive Take the medication for 20 weeks and use the same training program and dietary rations. After 20 weeks of continuous injection experiments, the average pure muscle growth of the highest dose group E (600mg per week) reached 8kg.
We mentioned that testosterone can also promote fat decomposition. Here are the results of the clinical experiment: the high-dose group-group D and group E increased muscle while also reducing fat. Unfortunately, the training plan and diet plan used in this clinical study were both It is based on the purpose of "building muscle" without any optimization for fat loss, otherwise the fat loss results of groups D and E should be better.
Next is strength growth. In this clinical study, the leg press was used as a strength reference movement: the leg press strength of the high-dose group improved significantly, reaching 75-78kg.
In addition, from the above research, we can find that the effect of testosterone is proportional to its dose. The greater the dose, the better the effect of increasing muscle strength. This is different from the situation of Dianabol, Stanozolol, etc. The highest dose of Dianabol is 50mg per day. If this dose is exceeded, It hardly brings any obvious benefits. Instead, it is directly excreted as waste. Studies have proven that the ideal dosage of testosterone is 300mg-1000mg/week. Of course, there are always differences between the research results and the user’s experience. The experience of a large number of athletes has proven that the optimal dosage range for using testosterone can be 400mg-1500mg/week. Some people even use 3000mg/week.A super-large dose of g(testosterone enanthate) Of course, that is a special case.
3. Side effects
Whether it is the minimum dose of 300mg/week from the research results or the minimum dose of 400mg/week from the athletes' experience results, it greatly exceeds the maximum testosterone secretion of 77mg/week in normal people. The so-called "quantitative changes lead to qualitative changes", especially in terms of side effects, although testosterone is The most natural hormone secreted by the human body and most suitable for the human body, but it will show some unpleasant side effects when used in high doses
First of all, testosterone, as a male hormone, mainly provides two functions: the anabolic ability of "promoting anabolism" and the sex hormone ability of "maintaining male characteristics" (androgenic effect). We have just mentioned the muscle-building effect of testosterone ( Promote anabolism) is proportional to the dose. Similarly, its androgenic ability as a sex hormone to "maintain male characteristics" is also proportional to the dose. When the dose reaches a certain level, the androgenic effect may be too strong. This brings about: "hair loss, oily skin, facial acne, hoarse voice, increased body hair, prostate enlargement, etc." Embarrassing male-oriented problems
This is not enough. These are all visible. There are also invisible: "increased blood pressure, reduced secretion of internal testosterone, and reduced sperm production."
This is not enough. The above are just male-oriented side effects. The trouble is that high doses of foreign testosterone can also bring "female-oriented" side effects. Testosterone is affected by the "aromatase" in the human body and is converted into estrogen. Originally, the male body maintains an appropriate concentration of estrogen. Sex hormones can bring many benefits (such as improving immunity, maintaining bone density, etc.), but "quantitative changes lead to qualitative changes". High doses of foreign testosterone will also be excessively converted into estrogen if there are high concentrations of estrogen in the male body. . "Gale breast development, increased body fat, water storage in the body, and testicular atrophy." Such embarrassing "female-oriented" side effects will happen to all of you macho men.
Are you scared? It needs to be explained here that most of the above-mentioned side effects are related to genetics and family history, which means that these side effects generally will not occur unless you have a family history of this problem, such as hair loss. Male pattern baldness is caused by A genetic disease carried by the X chromosome means that if your motherIf your parents (such as your grandfather) have this kind of alopecia, you are likely to experience the side effects of hair loss when using testosterone
The culprit of androgenic side effects is not testosterone itself but dihydrotestosterone (DHT), which is converted from testosterone through the "5-Alpha-Reduce enzyme". DHT has a much stronger androgenic effect than testosterone, but it has the ability to promote anabolism. However, it is very low. DHT is very easy to attach to the androgen receptors of the scalp and prostate, so the stimulation of these two areas is particularly strong, causing hair loss and prostatic hypertrophy
The countermeasures are: 1. Prevent the conversion of testosterone into DHT 2. Prevent DHT from binding to the male hormone receptor. For example, "Ketoconazole" and "Finasteride" can reduce the "5-Alpha-Reduce enzyme" "The activity reduces the conversion of testosterone to DHT and also blocks the connection between DHT and androgen receptors to protect hair and prostate.
Of course, it is worth reminding that almost all male-tropic side effects are genetically sensitive. If you do not have a corresponding family genetic history, then you do not need to consider countermeasures because they will almost never occur.
Compared with male side effects, female side effects are really something that must be taken seriously because most men are allergic to estrogen. A slightly higher level of estrogen in the body may cause female problems such as nipple swelling, water storage, and edema. Of course, If you are lucky enough to have an estrogen-inert constitution, then congratulations, you almost don’t have to think about the “anti-oestrogen” thing that is going to happen next. What? Start praying that you are an estrogen-inert constitution? I have bad news here. Almost all fat guys are sensitive to estrogen, but thin guys are not necessarily inert
Anti-drugs are "Nolvadex" (Nolvadex) or "Arimidex" (Anatozole). They can reduce the activity of aromatase, reduce the conversion of testosterone to estrogen, and prevent estrogen from binding to its receptors, thereby preventing females from converting to estrogen. Side effects
It should also be reminded here that since anti-estrogens have a "pro-catabolic" effect, it is recommended to have these drugs on hand at all times. Once feminizing symptoms (such as nipple itching) occur, administer them immediately until the symptoms disappear rather than during the entire testosterone medication period. All use anti-estrogens
4. Selection and use of testosterone products
However, if pure testosterone is directly used for injection, the pain will be almost torture-level. In addition, its active time is only 1 day - so short that it must be injected every day (suffering torture every day.) Therefore, almost no one is willing to directly inject pure testosterone. Testosterone
Fortunately, people have found a way to solve these two problems (pain, too short active time) at the same time, which is to lipidate testosterone to produce, for example: testosterone propionate, testosterone enanthate, and testosterone cypionate. Wait, they are all simple lipids of testosterone, that is, an extra "fat chain" is added to the original testosterone molecule. For example, testosterone propionate is added to the testosterone molecule with a propionate fatty chain. Testosterone enanthate is added to the testosterone molecule. An enanthate lipid chain.
These lipid compounds are oil-based drugs that will not cause too much pain when inserted into the muscles. More importantly, the lipidated testosterone can have a longer active effect time, which is also convenient to use and does not need to be used every day like pure testosterone. Butt piercing should be done every 3 or 4 days or once a week.
After the lipidated testosterone enters the body, the "lipase" in the body will slowly engulf the lipid chains attached to the testosterone molecule and release the real effective component - testosterone. Due to the existence of this release process, testosterone can slowly And it continues to spread from the injection site to the whole body, thus providing a longer active time
There are many kinds of testosterone esters, 5 or 6 of which are commonly used by athletes. The difference between them is that the lipid chains attached to the testosterone molecules are different. Generally speaking, the shorter the lipid chain, the faster the release. The longer the lipid chain, the faster the release. Slow means that the longer the lipid chain of testosterone, the longer its activity time. For example, testosterone propionate, the chemical formula of the propionic acid chain is C3H6O2. There are 3 carbon atoms in the entire lipid chain, and its activity time is 2-3 days, while enanthate acid The chemical formula of the aliphatic chain is C7 H12 O. There are 7 carbon atoms in the entire aliphatic chain. The aliphatic chain is longer than that of testosterone propionate, so its activity time is also longer, which is 15 days.
The advantage of a long testosterone release time is that you don’t have to pierce your butt frequently. In addition, the relatively gentle release speed can ensure that the testosterone level in the body is stable and will not have frequent ups and downs, so that the body does not have to be tired of adapting back and forth between the peaks and troughs of testosterone. Guarantee stable muscle gain effect.
However, long lipid chains are not only beneficial. In fact,long lipid chains also have three disadvantages:
First, the lipid chain accounts for a certain weight in the entire testosterone lipid content.
For example, testosterone enanthate has a molecular weight of 412 Among them, the really useful ingredient - testosterone, has a molecular weight of 288, which means that the testosterone content in testosterone enanthate is 288/412=70%, and the corresponding shorter aliphatic chain testosterone propionate has a molecular weight of 362 and its testosterone content is 288 /362=80% When purchasing and using testosterone esters, the nominal concentration (such as 100mg/ml) refers to the content of the entire testosterone esters rather than the content of pure testosterone contained in it, such as a bottle of 2ml The concentration of Testosterone Propionate Injection is 100mg/ml, then it contains 100mg/ml × 2ml = 200mg of Testosterone Propionate, and the real useful ingredient (testosterone) is 200mg × 80% = 160mg, which corresponds to the same concentration of Testosterone Enanthate. The total amount of testosterone contained is 100mg/ml × 2ml ×70% = 140mg. It can be seen that all testosterone lipids contain "condiments". Removing these "condiments" is the truly useful "main course". However, no matter it is Whether it's the main course or the condiments, they all cost you money. So for the sake of your wallet, should you endure the pain and pierce your butt every day?
Second, longer lipid chains slow down the speed at which blood drug concentrations reach peak levels.
As mentioned before, the muscle-building effect of testosterone is proportional to the dose. In fact, a more accurate statement is: "The muscle-building effect of testosterone is proportional to its concentration in the blood (blood drug concentration)." However, due to the presence of long-chain lipids, Due to the slow conversion rate of lipase, it will take a long time for the blood concentration of testosterone to reach its peak. For example, it would take up to 8 weeks for testosterone enanthate to release testosterone and reach its peak blood concentration. Before that, it would not be 100. % enjoy the muscle-building effect brought by drugs (and your Money). Fortunately, we have a good way to solve this problem, which is the "FrontLoading technique" (Note: I will find information for you to discuss separately in the future)
Third, long-chain lipids have greater estrogenic side effects.
Don’t you think it’s a little strange? Doesn’t it mean that all testosterone esters have the same active ingredient-testosterone? The estrogenic side effect is because testosterone is converted into estrogen. Since all testosterone esters ultimately release the same thing, why? Will long-chain lipids cause more serious estrogenic side effects?
Female conversion is performed by "aromatase"; Caused by the fact that the amount of aromatase in the human body is limited, it has to wait for the body to regenerate after it is consumed. If short-chain lipid testosterone is used to quickly release the aromatase, it is also rapidly consumed. It cannot wait for the body to regenerate testosterone and has already joined or transformed it with the receptor. It becomes DHT, but the situation with long-chain lipids is different. On the one hand, the body is slowly rebuilding aromatase. On the other hand, testosterone is also continuously and slowly released by long-chain lipids, so aromatase has enough raw materials at any time to carry out "rebellion". "It can be said to be "in utter embarrassment".
It can be seen that short has short advantages and long has advantages. They cannot replace each other. It is the best plan to choose according to the situation.
Let me introduce to you the two most common testosterone esters
The first is Testosterone Propionate
Active time: 2-3 days
Effective dosage: 350mg-2000mg/ week
Injection cycle: once every 2 days
Drug test avoidance: 3 weeks
How to use:
Stack A: Due to its small feminizing effect, it is not easy to cause water storage, so it is used in the "Cutting cycle" (tightening cycle, which means a cycle that focuses on high-quality muscles and lines. It increases muscle and removes fat at the same time. The effect is also very impressive) It is natural to choose steroids that are not aromatic or have very little aromatic effect to be used in combination with it, such as Boldenone, Stanozolol, etc. to ensure that the highest quality muscles are obtained during the muscle building process. Rather than muscle + fat + a lot of water
Overlay B: Compared with the "Cutting cycle", the "Bulking cycle" (which maximizes the muscle-building effect and almost ignores the effects of fat and water storage) is still more tempting to spend the same money. The former's muscle-building effect is only about the latter. 25%. So wouldn’t it be a pity if an almost universal steroid like testosterone propionate cannot be used in the “Bulking cycle”? So I will provide you with another superimposed method for the “Bulking cycle” that is—— When combined with testosterone enanthate (plus DECA), you may be wondering, "Aren't they all testosterone esters? Isn't it enough to just use one?" Because testosterone propionate releases quickly and can take effect quickly, while enanthate acid Testosterone is slower, but frequent injections of testosterone propionate are really difficult.Bear. Testosterone enanthate is very slow to reach the peak blood concentration, so you can consider using the two together at the beginning of the cycle. The former can quickly put the body into a muscle-building state. After 2-3 weeks, testosterone enanthate has begun to take effect. Testosterone propionate can be withdrawn
Overlay C: In fact, this is the best overlay method of using testosterone propionate, which is the "KickStart" method developed from type B above (choose a high-speed release drug at the beginning of the cycle to quickly release the drug into the blood The concentration reaches the peak, causing the body to immediately enter a muscle-building state to leave buffer time for the long-acting injections that follow). Specifically, it is "testosterone propionate + any long-acting injection", such as testosterone propionate + DECA, testosterone propionate + trenbolone. The specific principle is as mentioned in B
Experienced brothers may have questions again, "Wouldn't it be better to use Dianabol if you want to KickStart? It is very convenient to take Dianabol orally without having to get an injection every two days." The reason is that Dianabol is a 17aa product, which puts a lot of pressure on the liver and is a perfect product. The Bulking cycle will add cutting drugs such as Stanozolol in the last 4 or 5 weeks of the cycle to absorb water. Stanozolol is also a 17aa product. As a result, the liver is under heavy pressure at the beginning and end of the cycle, so Dianabol is replaced with C. Testosterone acid will reduce the pressure on the liver a lot.
Next is Testosterone Enanthate
Active time: 2 weeks
Effective dosage: 400mg-2000mg/ week
Injection cycle: once a week
Drug test avoidance: 3 months
How to use:
The method of using long-chain lipids is relatively simple. It is generally used as the basic drug in the Bulking cycle and then combined with almost any kind of other long-acting injections. It should be noted that the dosage should be at least the same or even slightly higher than that of the long-acting injections. The use time should also be slightly longer than other long-acting injections.
For example:
Using Deca as the main drug in the cycle, the ratio of testosterone enanthate in the cycle should be similar to the following:
Deca 400mg per week for 12 weeks
Testosterone enanthate 500mg per week for 13 weeks, 900mg in the first week for FrontLoading
Stanozolol 40mg daily for the last 5 weeks
Why should the dosage of Testosterone Enanthate be arranged in this way?What about the amount? Because most long-acting injections have a strong suppressive effect on endogenous testosterone, causing a decline in sexual desire, and in severe cases, it may cause the inability to maintain male physical signs. Therefore, external testosterone must be added to counteract this ability to resist suppression. It is a positive use of the side effects of testosterone.
❋ Tags: